D. H. Hall

NEKL-4 regulates microtubule stability and mitochondrial health in C. elegans ciliated neurons

This study shows NEKL-4 regulates ciliary stability and mitochondrial health in C. elegans ciliated neurons through kinesin activation and mitochondrial homeostasis.

Cell-specific alpha-tubulin TBA-6 and pan-ciliary IFT cargo RAB-28 generate a non-canonical transition zone

The paper identifies cell-specific tubulin and IFT cargo proteins that generate a non-canonical transition zone in cilia through microtubule loss and reorganization.

Ciliary intrinsic mechanisms regulate dynamic ciliary extracellular vesicle release from sensory neurons

This study identifies ciliary intrinsic mechanisms that regulate dynamic extracellular vesicle release from sensory neurons in C. elegans, showing that KLP-6 and TTM-5 are required for sustained release.

Intermediate Filaments Associate with Aggresome-like Structures in Proteostressed C. elegans Neurons and Influence Large Vesicle Extrusions as Exophers

This study shows that intermediate filaments in C. elegans neurons form aggresome-like structures under proteostress and influence exopher production for aggregate removal.

A Rapid in vivo Pipeline to Identify Small Molecule Inhibitors of Amyloid Aggregation

This paper presents an in vivo pipeline to identify small molecule inhibitors of amyloid aggregation by screening compounds that suppress crystal formation in C. elegans.

A genetic screen identifies new steps in oocyte maturation that enhance proteostasis in the immortal germ lineage

The paper identifies genes involved in oocyte maturation that enhance proteostasis in C. elegans germline through lysosomal acidification and mitochondrial functions.

A ciliary BBSome-ARL-6-PDE6D pathway trafficks RAB-28, a negative regulator of extracellular vesicle biogenesis

This study identifies a ciliary pathway involving RAB28, BBSome, and PDE6D that regulates extracellular vesicle biogenesis and homeostasis in C. elegans sensory organs.

Cell type-specific structural plasticity of the ciliary transition zone in C. elegans

The paper shows that ciliary transition zones in C. elegans sensory neurons are structurally plastic, changing during development in a cell type-specific manner.

C. elegans DBL-1/BMP Regulates Lipid Accumulation via Interaction with Insulin Signaling

This study shows DBL-1/BMP signaling in C. elegans regulates lipid accumulation through interaction with insulin signaling, affecting lipid droplet size and count.

Distinct effects of tubulin isotype mutations on neurite growth in Caenorhabditis elegans

The paper examines the effects of tubulin isotype mutations on neurite growth in C. elegans, identifying three mutation types with distinct impacts on microtubule stability and neuronal development.