M. S. Silva

Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants

This paper computationally redesigns an antibody to restore potency against SARS-CoV-2 Omicron subvariants while maintaining efficacy against Delta and other variants.

A unique chaperoning mechanism in Class A JDPs recognizes and stabilizes mutant p53.

This study identifies a unique chaperoning mechanism in class-A JDPs that recognizes and stabilizes mutant p53, promoting cancer progression by preventing its degradation.

Cell-specific alpha-tubulin TBA-6 and pan-ciliary IFT cargo RAB-28 generate a non-canonical transition zone

The paper identifies cell-specific tubulin and IFT cargo proteins that generate a non-canonical transition zone in cilia through microtubule loss and reorganization.

Viral route of infection determines the effect of Drosophila melanogaster gut bacteria on host resistance and tolerance to disease.

This study investigates how gut bacteria in Drosophila melanogaster affect host resistance and tolerance to viral infections, finding that their impact varies by infection route and is less pronounced than Wolbachia's effects.

Sensory cilia act as a specialized venue for regulated EV biogenesis and signaling

This study identifies ciliary tip and base as distinct sites for EV shedding in C. elegans and shows ciliary trafficking machinery regulates EV biogenesis and signaling.

Humic acids enrich the plant microbiota with bacterial candidates for the suppression of pathogens

This study shows that humic acids enrich plant root microbiota with bacteria capable of suppressing pathogens by degrading fungal and nematode compounds and promoting plant growth.

Sodium Diethyldithiocarbamate antiparasitic activity against different Trypanosoma cruzi strains: Insights of its biological activity

This study evaluates the antiparasitic activity of sodium diethyldithiocarbamate (DETC) against various strains and forms of Trypanosoma cruzi, finding it effective with varying IC50 values and mitochondrial damage.

Cell type-specific structural plasticity of the ciliary transition zone in C. elegans

The paper shows that ciliary transition zones in C. elegans sensory neurons are structurally plastic, changing during development in a cell type-specific manner.