Author

K. C. Nguyen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Approach:genetic perturbation / CRISPR· 3 Assay:proteomics· 3 Research Focus:development & morphogenesis· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

D. H. Hall· 4 shared K. M. Power· 2 shared M. M. Barr· 2 shared A. Burns· 1 shared A. J. Smart· 1 shared A. Silva· 1 shared B. D. Grant· 1 shared C. N. Cruz· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersCell Biology

D. H. Hall

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

NEKL-4 regulates microtubule stability and mitochondrial health in C. elegans ciliated neurons

K. M. Power, K. C. Nguyen, A. Silva, S. Singh, D. H. Hall, C. Rongo, M. M. Barr

This study shows NEKL-4 regulates ciliary stability and mitochondrial health in C. elegans ciliated neurons through kinesin activation and mitochondrial homeostasis.

bioRxiv · Feb 14, 2024 · PreprintCell Biology

Ciliary intrinsic mechanisms regulate dynamic ciliary extracellular vesicle release from sensory neurons

J. Wang, J. Saul, I. A. Nikonorova, C. N. Cruz, K. M. Power, K. C. Nguyen, D. H. Hall, M. M. Barr

This study identifies ciliary intrinsic mechanisms that regulate dynamic extracellular vesicle release from sensory neurons in C. elegans, showing that KLP-6 and TTM-5 are required for sustained release.

bioRxiv · Nov 1, 2023Cell Biology

Intermediate Filaments Associate with Aggresome-like Structures in Proteostressed C. elegans Neurons and Influence Large Vesicle Extrusions as Exophers

M. L. Arnold, J. F. Cooper, R. Androwski, S. Ardeshna, I. Melentijevic, A. J. Smart, R. J. Guasp, K. C. Nguyen, G. Bai, D. H. Hall, B. D. Grant, M. Driscoll

This study shows that intermediate filaments in C. elegans neurons form aggresome-like structures under proteostress and influence exopher production for aggregate removal.

bioRxiv · Aug 3, 2022 · PreprintCell Biology

A Rapid in vivo Pipeline to Identify Small Molecule Inhibitors of Amyloid Aggregation

M. Kamal, J. Knox, R. I. Horne, O. S. Tiwari, A. Burns, D. Han, D. L. Bar-Yosef, E. Gazit, K. C. Nguyen, D. H. Hall, M. Vendruscolo, P. J. Roy

This paper presents an in vivo pipeline to identify small molecule inhibitors of amyloid aggregation by screening compounds that suppress crystal formation in C. elegans.

bioRxiv · Apr 11, 2022 · PreprintPharmacology & Toxicology

Extracellular 2’3’-cGAMP is an immunotransmitter produced by cancer cells and regulated by ENPP1

J. A. Carozza, V. Boehnert, K. C. Nguyen, G. Skariah, K. E. Shaw, J. A. Brown, M. Rafat, R. von Eyben, E. E. Graves, J. S. Glenn, M. Smith, L. Li

The paper identifies extracellular 2’3’-cGAMP as an immunotransmitter released by cancer cells, regulated by ENPP1, and shows its therapeutic potential in tumor treatment.

bioRxiv · Oct 7, 2019Biochemistry