Author

M. MacKay

BC Children's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Genetic & Genomic Medicine· 1 Immunology· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

C. Mason· 2 shared C. Meydan· 2 shared E. Afshinnekoo· 2 shared J. Foox· 2 shared A. Beheshti· 1 shared A. C. Borczuk· 1 shared A. Cesano· 1 shared A. Corvelo· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

C. Mason

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Assessment of adaptive functioning in Angelman syndrome using the Vineland Adaptive Behavior Scales, Third Edition

Sarah Nelson Potter, Julia Zhang, Batsheva Friedman, Julia M. Gable, Nadia Ali, Rene L. Barbieri‐Welge, Ayala Ben-Tall, Kelly E. Caravella, Margaret DeRamus, Dea Garic, M. MacKay, Kara Murias, Sarika U. Peters, Kimberly Smyth, Jane Summers, , Anjali Sadhwani

This study tracks adaptive functioning in Angelman syndrome using Vineland-3, finding slower growth in deletion subtypes and parallel developmental trajectories across subtypes.

medRxiv · Jun 22, 2026 · PreprintGenetic & Genomic Medicine

Hypoxic memory of tumor intrinsic type I interferon suppression promotes breast cancer metastasis

O. Iriondo, D. Mecenas, Y. Li, C. R. Chin, A. Thomas, Y. Amzaleg, A. Moriarty, V. Ortiz, M. MacKay, A. Dickerson, G. Lee, S. Harotoonian, B. A. Benayoun, A. D. Smith, C. Mason, , M. Yu

The paper shows hypoxia induces a long-lasting suppression of type I interferon and antigen presentation in breast cancer cells, enhancing metastasis and being reversible with HDACi and immunotherapy.

bioRxiv · May 12, 2022 · PreprintCancer Biology

A Modified Comprehensive Grading System for Murine Knee Osteoarthritis: Scoring the Whole Joint as an Organ

C. Grote, M. Mackay, X. Liu, Q. Lu, J. Wang

This paper introduces a new histologic grading system for murine knee osteoarthritis that scores the entire joint, showing high reproducibility and sensitivity for detecting OA progression.

bioRxiv · May 5, 2021Pathology

Systemic Tissue and Cellular Disruption from SARS-CoV-2 Infection revealed in COVID-19 Autopsies and Spatial Omics Tissue Maps

J. Park, J. Foox, T. Hether, D. Danko, S. Warren, Y. Kim, J. Reeves, D. J. Butler, C. Mozsary, J. Rosiene, A. Shaiber, E. Afshinnekoo, M. MacKay, Y. Bram, V. Chandar, , Schwar

This study identifies systemic tissue and cellular disruption from SARS-CoV-2 infection using autopsy and spatial omics data, showing tissue-specific damage and transcriptional changes.

bioRxiv · Mar 8, 2021 · PreprintMicrobiology

Cell-free DNA (cfDNA) and exosome profiling from a year-long humanspaceflight reveals circulating biomarkers

D. Bezdan, K. Grigorev, C. Meydan, F. Pelissier Vatter, M. Ciofi, V. Rao, K. Nakahira, P. Burnham, E. Afshinnekoo, C. Westover, D. Butler, C. Moszary, M. MacKay, J. Foox, T. Mishra, , C. Mason

This study profiles cfDNA and exosomes from an astronaut during a year-long spaceflight, identifying increased cf-mtDNA and exosomal brain-derived peptides as potential biomarkers of spaceflight-related stress.

bioRxiv · Nov 8, 2020Cell Biology

A Systems Immunology Approach Identifies Cytokine-Induced STAT Signaling Pathways Critical to Rheumatoid Arthritis Disease Activity and Treatment Response

S. L. Bridges, J. Ptacek, R. E. Hawtin, D. Sun, B. Louie, E. Evensen, B. Mittleman, A. Cesano, G. Cavet, C. O. Bingham, S. S. Cofield, J. R. Curtis, M. I. Danila, C. Raman, R. Furie, , P. K. Gregersen

bioRxiv · Jul 8, 2019 · PreprintImmunology