Author

C. R. Chin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

T. Jacks· 2 shared A. B. Miller· 1 shared A. Chadburn· 1 shared A. D. Smith· 1 shared A. Dickerson· 1 shared A. K. Shalek· 1 shared A. M. Darnell· 1 shared A. M. Melnick· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersCancer Biology

T. Jacks

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4 papers

Recent·Most cited

Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B cell fate decisions and yields T cell-depleted lymphomas

J. Li, C. R. Chin, H.-Y. Ying, C. Meydan, M. R. Teater, M. Xia, P. Farinha, K. Takata, C.-S. Chu, M. A. Rivas, A. Chadburn, C. Steidl, D. W. Scott, R. G. Roeder, C. E. Mason, , A. M. Melnick

This study shows that combined loss of CREBBP and KMT2D disrupts super-enhancer function in B cells, leading to immune evasion and T cell depletion in lymphomas.

bioRxiv · Feb 13, 2023Cancer Biology

Hypoxic memory of tumor intrinsic type I interferon suppression promotes breast cancer metastasis

O. Iriondo, D. Mecenas, Y. Li, C. R. Chin, A. Thomas, Y. Amzaleg, A. Moriarty, V. Ortiz, M. MacKay, A. Dickerson, G. Lee, S. Harotoonian, B. A. Benayoun, A. D. Smith, C. Mason, , M. Yu

The paper shows hypoxia induces a long-lasting suppression of type I interferon and antigen presentation in breast cancer cells, enhancing metastasis and being reversible with HDACi and immunotherapy.

bioRxiv · May 12, 2022 · PreprintCancer Biology

Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice

B. Hamza, A. B. Miller, L. Meier, M. Stockslager, E. M. King, S. R. Ng, K. L. DeGouveia, N. Mulugeta, N. L. Calistri, H. Strouf, L. Lin, C. R. Chin, R. Weinberg, A. K. Shalek, T. Jacks, S. Manalis

This study measures CTC kinetics and metastatic potential by exchanging blood between tumor-bearing and healthy mice, finding short CTC half-life and high shedding rates.

bioRxiv · Nov 1, 2020Cancer Biology

Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma

A. N. Lau, Z. Li, L. V. Danai, A. M. Westermark, A. M. Darnell, R. Ferreira, V. Gocheva, S. Sivanand, E. C. Lien, K. M. Sapp, J. R. Mayers, G. Biffi, C. R. Chin, S. M. Davidson, D. A. Tuveson, , M. Vander Heiden

The paper uses isotope tracing to compare metabolism between cancer cells and fibroblasts in pancreatic tumors, identifying key metabolic dependencies in cancer cells.

bioRxiv · Mar 9, 2020Cancer Biology