OPA1 Deletion in Brown Adipose Tissue Improves Thermoregulation and Systemic Metabolism via FGF21
R. O. Pereira, A. Marti, A. C. Olvera, S. M. Tadinada, S. H. Bjorkman, E. T. Weatherford, M. Westphal, P. H. Patel, A. K. Kirby, R. Hewezi, W. Bui Tran, L. M. G. Pena, R. A. Souvenir, M. Mital, C. M. Adams, , E. D. Abel
This study shows that deleting OPA1 in brown adipose tissue enhances thermoregulation and metabolism through the ATF4-FGF21 pathway, independent of thermogenesis.
bioRxiv · Jan 4, 2021Physiology