S. Chandran

Robust acidic pH and digestive enzyme stability of anti-SarsCov2 IgY antibodies: Implications for treatment of viral transmission thru gastrointestinal, ocular, nasal and skin tissues

The paper evaluates the stability of anti-SARS-CoV-2 IgY antibodies at acidic pH and against trypsin digestion, supporting their use in treating viral transmission through acidic environments.

Targeted neutralizing IgY antibodies against SGLT1 glucose transporter reduce glucose uptake and improve glycemic profile in vivo

An Anti-diabetic Nutraceutical enhances muscle cell glucose uptake of cardiometabolic drugs

The paper tests an anti-diabetic nutraceutical's ability to enhance glucose uptake in muscle cells when combined with cardiometabolic drugs, showing potential for improved glucose control.

Human Bone Marrow Plasma Cell Atlas: Maturation and Survival Pathways Unraveled by Single Cell Analyses

The study maps human bone marrow plasma cell heterogeneity using single-cell transcriptomics, revealing maturation pathways and molecular features of long-lived plasma cells.

Suppression of insulin stimulated muscle glucose uptake by non-caloric sweetener sucralose and its reversal by an antidiabetic nutraceutical supplement

The paper investigates how non-caloric sweeteners like sucralose affect muscle glucose uptake and shows that a nutraceutical can reverse this effect.

Investigation into the Phenological Patterns of Trees in Socorro Plateau, Goa

This study analyzes the phenological patterns of trees in Socorro Plateau, Goa, to identify climate change impacts and ecological variations.

Nutraceutical supplement targeting multiple molecular steps synergistically enhances muscle glucose uptake and improves in vivo oral glucose disposal

This study shows a combination of vitamins improves glucose uptake and disposal in pre-diabetes and type 2 diabetes through multiple molecular targets.

A 3-Dimensional bioprinted human gut-liver axis model for studying Alcoholic Liver Disease

This study develops a 3D bioprinted gut-liver axis model to investigate how Cytolysin and ethanol together cause intestinal damage in Alcoholic Liver Disease.

Differential Activity of Repurposed Drugs as Receptor Binding Domain Antagonists for Omicron and Native Strains of SarsCov2

The paper tests repurposed drugs as antagonists of SARS-CoV-2 RBD binding, finding that iodine-containing drugs are ineffective against Omicron.

Edible formulations of chicken egg derived IgY antibodies neutralize SarsCoV2 Omicron RBD binding to human ACE2

This study develops edible IgY antibodies from chicken eggs that neutralize Omicron RBD binding to human ACE2 and formulates them into beverages for oral use.

NaCl Triggers the Sessile-to-Motile Transition of Bacillus subtilis

This study investigates how NaCl affects the sessile-to-motile transition in Bacillus subtilis by altering biofilm dynamics and gene regulation.

Quantifying the patterns of metabolic plasticity and heterogeneity along the epithelial-hybrid-mesenchymal spectrum in cancer

The paper analyzes metabolic pathway associations with EMT status across cancer datasets, revealing both general trends and heterogeneity in metabolic plasticity.

Preparation of ingestible antibodies to neutralize the binding of SarsCoV2 RBD (receptor binding domain) to human ACE2 Receptor

This study produces chicken-derived IgY antibodies against SARS-CoV2 RBD to neutralize ACE2 binding, effective against the delta variant, and proposes their use as ingestible passive immunotherapy.

The landscape of extrachromosomal circular DNA in medulloblastoma

This study identifies ecDNA in 18% of medulloblastoma patients, linking it to higher relapse and mortality rates and suggesting enhancer rewiring as an oncogenic mechanism.

Genome sequencing and molecular characterisation of XDR Acinetobacter baumannii reveal complexities in resistance: Novel combination of Sulbactam-Durlobactam holds promise for therapeutic intervention

This study characterizes drug resistance in XDR Acinetobacter baumannii isolates and evaluates the efficacy of the novel Sulbactam-Durlobactam combination against carbapenemases.

Identification of SGLT2 inhibitor Ertugliflozin as a treatment for COVID-19 using computational and experimental paradigm

This study identifies Ertugliflozin as a potential treatment for COVID-19 through computational screening and experimental validation of its ability to inhibit RBD-ACE2 binding and modulate inflammatory responses.

Tyrosine Kinase Inhibitor Family of Drugs as Prospective Targeted Therapy for COVID-19 Based on In Silico And 3D-Human Vascular Lung Model Studies

This study evaluates four tyrosine kinase inhibitors for their anti-inflammatory and anti-thrombogenic effects against COVID-19 using in silico and 3D-human vascular lung models, suggesting they could be repurposed as targeted therapies.

In silico and in vitro Demonstration of Homoharrintonine Antagonism of RBD-ACE2 Binding and its Anti-inflammatory and anti-thrombogenic Properties in a 3D human vascular lung model

This paper identifies Homoharringtonine as a potential repurposed drug for COVID-19 by demonstrating its ability to block RBD-ACE2 binding and show anti-inflammatory and anti-thrombogenic effects in a 3D human vascular lung model.

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

The paper generates 24 induced pluripotent stem cell lines from members of the Lothian Birth Cohort 1936 to study cognitive ageing and neurodegenerative disease resilience.

Removal of a subset of non-essential genes fully attenuates a highly virulent Mycoplasma strain

This paper attenuates a highly virulent Mycoplasma strain by deleting non-essential genes and demonstrates its safety in vivo using a goat model.