Author

J. P. Mesirov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 5

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Assay:scRNA-seq· 2 Assay:whole-genome sequencing· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

E. Fraenkel· 2 shared H. Carter· 2 shared J. D. Bui· 2 shared J. S. Gutkind· 2 shared M. Pagadala· 2 shared O. Harismendy· 2 shared R. J. Wechsler-Reya· 2 shared S. L. Pomeroy· 2 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

E. Fraenkel

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Developmental Basis of SHH Medulloblastoma Heterogeneity

M. P. Gold, W. Ong, A. M. Masteller, J. A. Galindo, N. R. Park, R. A. Saurez, M. C. Vladoiu, L. K. Donovan, A. D. Walker, J. Benetatos, L. Garzia, R. J. Wechsler-Reya, J. P. Mesirov, A. Korshunov, S. L. Pomeroy, , E. Fraenkel

The paper investigates SHH medulloblastoma heterogeneity by analyzing single-nucleus RNA-seq data and linking findings to developmental origins and molecular subtypes.

bioRxiv · Sep 2, 2022Cancer Biology

Lymphatic-Preserving Treatment Sequencing with Immune Checkpoint Inhibition Unleashes cDC1-Dependent Antitumor Immunity in HNSCC

R. Saddawi-Konefka, A. O'Farrell, F. Faraji, L. Clubb, M. M. Allevato, N.-A. A. S. Anang, S. M. Jensen, Z. Wang, V. H. Wu, B. S. Yung, R. Al Msari, I. Franiak Pietryga, A. A. Molinolo, J. P. Mesirov, A. B. Simon, , J. S. Gutkind

This study shows that lymphatic-preserving treatment sequences enhance cDC1-dependent antitumor immunity in HNSCC by avoiding lymphablation, which compromises ICI response.

bioRxiv · Feb 1, 2022Cancer Biology

The landscape of extrachromosomal circular DNA in medulloblastoma

O. S. Chapman, J. Luebeck, S. Wani, A. Tiwari, M. Pagadala, S. Wang, J. D. Larson, J. T. Lange, I. T.-L. Wong, S. R. Dehkordi, S. Chandran, M. Adam, Y. Lin, E. Juarez, J. T. Robinson, , L. Chavez

This study identifies ecDNA in 18% of medulloblastoma patients, linking it to higher relapse and mortality rates and suggesting enhancer rewiring as an oncogenic mechanism.

bioRxiv · Oct 18, 2021 · PreprintCancer Biology

Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response

M. Pagadala, V. H. Wu, E. Perez-Guijarro, H. Kim, A. Castro, J. Talwar, T. Sears, C. Gonzalez-Colin, S. Cao, B. Schmiedel, S. Goudarzi, D. Kirani, R. Salem, G. Morris, O. Harismendy, , H. Carter

The paper identifies germline variants associated with the tumor immune microenvironment, linking them to cancer risk and immunotherapy response.

bioRxiv · Apr 14, 2021 · PreprintCancer Biology

Single-cell characterization of step-wise acquisition of carboplatin resistance in ovarian cancer

A. T. Wenzel, D. Champa, H. Venkatesh, S. Sun, C.-Y. Tsai, J. P. Mesirov, J. D. Bui, S. B. Howell, O. Harismendy

The paper characterizes the step-wise acquisition of carboplatin resistance in ovarian cancer using single-cell gene expression analysis and identifies distinct transcriptional patterns associated with resistance.

bioRxiv · Feb 7, 2021Cancer Biology