Author

M. Pino

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:rat· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. A. Upadhyay· 3 shared A. K. Boddapati· 3 shared E. G. Viox· 3 shared G. K. Tharp· 3 shared J. L. Harper· 3 shared K. L. Pellegrini· 3 shared M. Paiardini· 3 shared R. D. Levit· 3 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersImmunology

A. A. Upadhyay

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques

T. N. Hoang, E. G. Viox, A. A. Upadhyay, Z. Strongin, G. K. Tharp, M. Pino, R. Nchioua, M. Hirschenberger, M. Gagne, K. Nguyen, J. L. Harper, S. Marciano, A. K. Boddapati, K. L. Pellegrini, J. Tisoncik-Go, , M. Paiardini

This study shows that modulating type I interferon responses in rhesus macaques reduces SARS-CoV-2 viral load and inflammation, suggesting a potential therapeutic strategy for severe COVID-19.

bioRxiv · Oct 21, 2022Immunology

TREM2+ and interstitial macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques

A. A. Upadhyay, T. N. Hoang, M. Pino, A. K. Boddapati, E. G. Viox, M. Y. H. Lee, J. Corry, Z. Strongin, D. A. Cowan, E. N. Beagle, T. R. Horton, S. Hamilton, H. Aoued, J. L. Harper, K. Nguyen, , S. E. Bosinger

This study identifies two macrophage populations driving inflammation in the lower airway during SARS-CoV-2 infection in rhesus macaques and shows baricitinib effectively reduces their influx and cytokine production.

bioRxiv · Oct 5, 2021 · PreprintMicrobiology

Siglec-1 on dendritic cells mediates SARS-CoV-2 trans-infection of target cells while on macrophages triggers proinflammatory responses

D. Perez-Zsolt, J. Munoz Basagoiti, J. Rodo, M. Elousa, D. Raich Regue, C. Risco, M. Sachse, M. Pino, S. Gumber, M. Paiardini, J. Chojnacki, I. Erkizia, X. Muniz, E. Ballana, E. Riveira Munoz, , N. Izquierdo-Useros

This study shows Siglec-1 on APCs mediates SARS-CoV-2 trans-infection and triggers proinflammatory responses, suggesting it as a potential therapeutic target.

bioRxiv · May 11, 2021 · PreprintMicrobiology

Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

T. N. Hoang, M. Pino, A. K. Boddapati, E. G. Viox, C. E. Starke, A. A. Upadhyay, S. Gumber, K. Busman-Sahay, Z. Strongin, J. L. Harper, G. K. Tharp, K. L. Pellegrini, S. Kirejczyk, K. Zandi, S. Tao, , Bosinger

This study shows baricitinib reduces lung inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques without affecting viral shedding or immune responses.

bioRxiv · Sep 16, 2020Immunology

Stitching together a nm thick peptide-based semiconductor sheet using UV light

A. Bolano Alvarez, M. Pino, S. B. Petersen, G. D. Fidelio

The paper demonstrates that specific retro-isomer peptides can form semiconductor-like monolayers with tunable electrical properties through UVB-induced crosslinking.

bioRxiv · Jul 1, 2020Biophysics