Author

M. Hirschenberger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:rat· 1

Frequent Co-Authors

F. Kirchhoff· 3 shared C. Conzelmann· 2 shared F. Zech· 2 shared J. A. Mueller· 2 shared J. Muench· 2 shared K. M. J. Sparrer· 2 shared R. Nchioua· 2 shared S. Klute· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersMicrobiology

F. Kirchhoff

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques

T. N. Hoang, E. G. Viox, A. A. Upadhyay, Z. Strongin, G. K. Tharp, M. Pino, R. Nchioua, M. Hirschenberger, M. Gagne, K. Nguyen, J. L. Harper, S. Marciano, A. K. Boddapati, K. L. Pellegrini, J. Tisoncik-Go, , M. Paiardini

This study shows that modulating type I interferon responses in rhesus macaques reduces SARS-CoV-2 viral load and inflammation, suggesting a potential therapeutic strategy for severe COVID-19.

bioRxiv · Oct 21, 2022Immunology

Imperfect innate immune antagonism renders SARS-CoV-2 vulnerable towards IFN-γ and -{lambda}

M. Hayn, M. Hirschenberger, L. Koepke, J. H. Straub, R. Nchioua, M. H. Christensen, S. Klute, C. Prelli Bozzo, W. Aftab, F. Zech, C. Conzelmann, J. A. Mueller, S. Srinivasachar Badarinarayan, C. M. Stuerzel, I. Forne, , K. M. J. Sparrer

This study identifies SARS-CoV-2's vulnerability to IFN-γ and -λ due to its inefficient antagonism of type I and II IFN responses, suggesting potential therapeutic strategies.

bioRxiv · Oct 15, 2020Microbiology

Alpha-1 antitrypsin inhibits SARS-CoV-2 infection

L. Wettstein, C. Conzelmann, J. A. Mueller, T. Weil, R. Gross, M. Hirschenberger, A. Seidel, S. Klute, c. Prelli-Bozzo, F. Zech, N. Preising, G. Fois, R. Lochbaum, P. Knaff, V. Mailaender, , J. Muench

The paper identifies 1-antitrypsin as a specific inhibitor of SARS-CoV-2, showing it blocks viral infection of human airway epithelium at physiological concentrations.

bioRxiv · Jul 2, 2020 · PreprintMicrobiology