S. Tao

Development of robust antiviral assays using relevant apical-out human airway organoids

This paper develops AORBs, a high-throughput human airway organoid system, to robustly assess antiviral efficacy against SARS-CoV-2 with high throughput and clinical relevance.

Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168

This study determines the cryo-EM structures of RNF168/UbcH5c-Ub/nucleosome complexes to elucidate the mechanism of H2A K13/K15 site-specific ubiquitination.

Enriched zones of embedded ribonucleotides are associated with DNA replication and coding sequences in the human mitochondrial genome

The paper identifies rNMP-enriched zones in human mtDNA linked to replication and coding sequences using ribose-seq across six cell types.

Tree and shrub richness modify subtropical tree productivity by modulating the diversity and community composition of soil bacteria and archaea

The paper examines how tree and shrub richness affects tree productivity by altering soil bacterial and archaeal diversity and composition in a subtropical forest experiment.

Elevated ozone concentration and nitrogen addition increase poplar rust severity by shifting the phyllosphere microbial community

This study shows elevated ozone and nitrogen addition increase poplar rust severity by altering phyllosphere microbial communities, with clone-specific responses observed.

Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

This study shows baricitinib reduces lung inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques without affecting viral shedding or immune responses.

Translational control of Bcl-2 promotes apoptosis of gastric carcinoma cells

This study shows that miR-383 suppresses Bcl-2 translation, promoting apoptosis in gastric carcinoma cells during chemotherapy.

Ischemic Preconditioning and Left Ventricular Dysfunction: A Novel Mechanism & Model for Pulseless Electrical Activity

This study shows ischemic preconditioning reduces ventricular fibrillation and prolongs pulseless electrical activity in animals with left ventricular dysfunction, offering a new model for human PEA arrest.

Template-assisted synthesis of adenine-mutagenized cDNA by a retroelement protein complex

The paper demonstrates that the DGR reverse transcriptase and Avd protein complex selectively mutagenize adenines during cDNA synthesis from DGR RNA templates.