Author

M. Praharaj

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. K. Singh· 2 shared J. Huang· 2 shared K. A. Lombardo· 2 shared T. J. Bivalacqua· 2 shared W. R. Bishai· 2 shared A. A. Ordonez· 1 shared A. Gupta· 1 shared A. Matoso· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

A. K. Singh

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Improved bladder cancer antitumor efficacy with a recombinant BCG that releases a STING agonist

P. K. Um, M. Praharaj, K. A. Lombardo, T. Yoshida, A. Matoso, A. S. Baras, L. Zhao, G. Srikrishna, J. Huang, P. Prasad, M. Kates, D. McConkey, D. M. Pardoll, W. R. Bishai, T. J. Bivalacqua

This study evaluates a recombinant BCG strain that releases a STING agonist, showing improved antitumor efficacy in bladder cancer models compared to wild-type BCG.

bioRxiv · Dec 15, 2023 · PreprintCancer Biology

Dynamic single-cell RNA sequencing reveals BCG vaccination curtails SARS-CoV-2 induced disease severity and lung inflammation

A. K. Singh, R. Wang, K. A. Lombardo, M. Praharaj, C. K. Bullen, P. Um, S. Davis, O. Komm, P. B. Illei, A. A. Ordonez, M. Bahr, J. Huang, A. Gupta, K. J. Psoter, S. K. Jain, , W. Bishai

This study uses single-cell RNA sequencing to show BCG vaccination reduces SARS-CoV-2 lung inflammation and disease severity by enhancing antibody production and altering immune cell transcriptional profiles.

bioRxiv · Mar 15, 2022 · PreprintImmunology

BCG overexpressing an endogenous STING agonist provides enhanced protection against pulmonary tuberculosis

W. R. Bishai, R. J. Dey, B. Dey, A. K. Singh, M. Praharaj

This study shows that BCG overexpressing a STING agonist provides better protection against tuberculosis in guinea pigs.

bioRxiv · Jul 9, 2018Microbiology