Tuft cell-derived acetylcholine regulates epithelial fluid secretion
T. E. Billipp, C. Fung, L. M. Webeck, D. B. Sargent, M. B. Gologorsky, M. M. McDaniel, D. N. Kasal, J. W. McGinty, K. A. Barrow, L. M. Rich, A. Barilli, M. Sabat, J. S. Debley, R. Myers, M. R. Howitt, J. von Moltke
This study shows that tuft cell-derived acetylcholine in the intestine triggers immediate fluid secretion, distinct from its role in immune responses, and is involved in Type 2 inflammation and helminth clearance.
bioRxiv · Mar 17, 2023 · PreprintImmunology