Author

M. R. Straus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

G. R. Whittaker· 3 shared S. Daniel· 3 shared T. Tang· 3 shared C. Klumpp-Thomas· 2 shared C. Z. Chen· 2 shared G. Whittaker· 2 shared H. Guo· 2 shared J. A. Jaimes· 2 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMicrobiology

G. R. Whittaker

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A high throughput screening assay for inhibitors of SARS-CoV-2 pseudotyped particle entry

M. Xu, M. Pradhan, K. Gorshkov, J. D. Petersen, M. Shen, H. Guo, W. Zhu, C. Klumpp-Thomas, S. Michael, M. Itkin, Z. Itkin, M. R. Straus, J. Zimmerberg, W. Zheng, G. Whittaker, C. Z. Chen

This paper develops a high throughput screening assay using SARS-CoV-2 pseudotyped particles to identify inhibitors of viral entry, finding 7 active compounds effective against both pseudotyped particles and live virus.

bioRxiv · Oct 4, 2021Pharmacology & Toxicology

Inhibitors of L-type calcium channels show therapeutic potential for treating SARS-CoV-2 infections by preventing virus entry and spread

M. R. Straus, M. Bidon, T. Tang, J. A. Jaimes, G. Whittaker, S. Daniel

This study tests L-type calcium channel blockers for inhibiting SARS-CoV-2 infection in cell culture, finding that felodipine and nifedipine limit virus entry and infection with minimal toxicity.

ACS Infectious Diseases · Sep 9, 2021Peer-reviewedMicrobiology

Proteolytic activation of SARS-CoV-2 spike at the S1/S2 boundary: potential role of proteases beyond furin

T. Tang, J. A. Jaimes, M. K. Bidon, M. R. Straus, S. Daniel, G. R. Whittaker

This study investigates the role of S1/S2 cleavage in SARS-CoV-2 spike protein activation, showing its necessity for early pathway entry in Calu-3 cells and involvement of proteases beyond furin.

bioRxiv · Oct 4, 2020Microbiology

Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS- S and MERS-S pseudotyped particles

C. Z. Chen, M. Xu, M. Pradhan, K. Gorshkov, J. Petersen, M. R. Straus, W. Zhu, P. Shinn, H. Guo, M. Shen, C. Klumpp-Thomas, S. G. Michael, J. Zimmerberg, W. Zheng, G. R. Whittaker

This paper identifies six broad-spectrum inhibitors of SARS-CoV-2 and MERS-CoV spike-mediated cell entry through drug repurposing screens using pseudotyped particles.

bioRxiv · Jul 10, 2020Pharmacology & Toxicology

Ca2+ ions promote fusion of Middle East Respiratory Syndrome coronavirus with host cells and increase infectivity

M. R. Straus, T. Tang, A. L. Lai, A. Flegel, M. Bidon, J. H. Freed, S. Daniel, G. R. Whittaker

This study shows that Ca2+ ions enhance MERS-CoV fusion and infectivity by interacting with specific residues in the spike protein's fusion peptide.

Journal of Virology · Jun 16, 2020Peer-reviewedMicrobiology