Author

T. Geng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

P. WANG· 6 shared D. Yang· 5 shared T. Lin· 4 shared A. G. Harrison· 3 shared E. Fikrig· 3 shared A. T. Vella· 2 shared G. Cheng· 2 shared L. Yang· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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6 shared papersImmunology

P. WANG

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Mix-and-extrude: high-viscosity sample injection towards time-resolved protein crystallography

M. Vakili, H. Han, C. Schmidt, A. Wrona, M. Kloos, I. de Diego, K. Dorner, T. Geng, C. Kim, F. Koua, D. Melo, M. Rappas, A. Round, E. Round, M. Sikorski, , J. Schulz

This paper introduces a mix-and-extrude method for time-resolved protein crystallography using 3D printed microchannels to study ligand-induced reactions in viscous media.

bioRxiv · Nov 23, 2022Biochemistry

Early detection of SARS-CoV-2 in circulating immune cells in a mouse model

T. Geng, S. Keilich, F. Tafas, P. WANG

This study detects SARS-CoV-2 RNA in immune cells of mice using RNA-FISH and FLSM, showing early dissemination of the virus in blood.

bioRxiv · Jun 30, 2021 · PreprintMicrobiology

An Essential Role of UBXN3B in B Lymphopoiesis

T. Geng, D. Yang, T. Lin, A. G. Harrison, B. Wang, B. Torrance, K. Wang, Y. Wang, L. Yang, L. Haynes, G. Cheng, A. T. Vella, E. Fikrig, P. WANG

This study identifies UBXN3B's critical role in B lymphopoiesis by maintaining BLNK stability and pre-BCR signaling, leading to impaired B cell development and increased vulnerability to viral infections.

bioRxiv · Mar 4, 2021 · PreprintImmunology

Differential roles of RIG-I-like receptors in SARS-CoV-2 infection

D. Yang, T. Geng, A. G. Harrison, P. WANG

This study investigates the roles of RIG-I and MDA5 in SARS-CoV-2 infection, finding that MDA5 is critical for type I/III IFN response while RIG-I has an IFN-independent antiviral effect.

bioRxiv · Feb 10, 2021Immunology

Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy

L. Yang, T. Geng, G. Yang, J. Ma, L. Wang, H. Ketkar, D. Yang, T. Lin, J. Hwang, S. Zhu, Y. Wang, J. Dai, F. You, G. Cheng, A. Vella, , P. WANG

This study shows that MSR1 restricts Chikungunya virus infection by activating autophagy through interactions with ATG12 and the ATG5-ATG12-ATG16L1 complex.

Communications Biology · Oct 8, 2020Peer-reviewedMicrobiology

A critical role for MSR1 in vesicular stomatitis virus infection of the central nervous system

D. YANG, T. Lin, A. G. Harrison, T. Geng, H. Wang, P. Wang

This study shows that MSR1 promotes VSV infection in the spinal cord by acting as a receptor, and its absence reduces viral load and mortality in mice.

bioRxiv · Jun 17, 2020Immunology

STING deficiency-associated aberrant CXCL10 expression contributes to pathogenesis of arthritogenic alphaviruses

T. Lin, T. Geng, A. Harrison, D. Yang, A. T. Vella, E. Fikrig, P. Wang

This study shows that STING deficiency increases CXCL10 expression, leading to higher viral loads and inflammation in alphavirus-induced arthritis in mice.

bioRxiv · May 13, 2020 · PreprintImmunology