MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors
M. Kilian, R. Sheinin, C. L. Tan, C. Kraemer, M. Friedrich, A. Kaminitz, K. Sanghvi, K. Lindner, F. Cichon, S. Jung, K. Jaehne, M. Ratliff, R. Prins, A. von Deimling, W. Wick, , M. Platten
This study shows that MHC class II antigen presentation on blood-borne myeloids is essential to maintain functional CD8+ T cells in brain tumors by preventing Tox-driven dysfunction.
Cancer Cell · Feb 1, 2023Peer-reviewedCancer Biology