K. Sanghvi

Employing RNA editing to engineer personalized tumor-specific neoantigens (editopes)

This paper develops a method to generate tumor-specific neoantigens using RNA editing, demonstrating its ability to create immunogenic epitopes that activate T cells and enhance immunotherapy potential.

What doesn't kill you makes you stronger? Effects of paternal age at conception on fathers and sons

This study investigates the effects of paternal age at conception on male survival, reproductive success, and offspring lifespan in Drosophila, finding no consistent deleterious effects and evidence of viability selection.

No general effects of advancing male age on ejaculates: a meta-analysis across the animal kingdom

This study conducts a meta-analysis of 1814 effect sizes from 379 studies to assess male reproductive senescence across species, finding no general pattern and highlighting taxonomic and methodological factors influencing results.

MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors

This study shows that MHC class II antigen presentation on blood-borne myeloids is essential to maintain functional CD8+ T cells in brain tumors by preventing Tox-driven dysfunction.

Effects of early and late life environments on ageing

This study examines how early and late life environments interact to affect ageing and fitness in seed beetles, finding sex- and trait-specific effects.

Sex-specific effects of developmental density on life history and age-dependent flight traits

This study examines how developmental crowding affects life history and flight traits in male and female seed beetles, finding sex-specific impacts on lifespan, fecundity, and age-dependent reproduction.