Author

D. C. Sarver

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 9 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:mouse· 9 Research Focus:cell type annotation· 6 Assay:bulk RNA-seq· 5 Research Focus:differential expression· 4 Research Focus:gene regulatory network inference· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 3

Frequent Co-Authors

G. W. Wong· 5 shared K. B. Sugg· 5 shared C. L. Mendias· 4 shared J. F. Markworth· 3 shared J. R. Talarek· 3 shared N. P. Disser· 3 shared S. V. Brooks· 3 shared K. R. Maddipati· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersPhysiology

G. W. Wong

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Author profile →

11 papers

Recent·Most cited

Loss of CTRP10 results in female obesity with preserved metabolic health

F. Chen, D. C. Sarver, M. Saqib, L. M. Velez, S. Aja, M. M. Seldin, G. W. Wong

This study shows that loss of CTRP10 in female mice leads to obesity without metabolic complications, highlighting a sex-dependent role in metabolic health.

bioRxiv · Nov 1, 2023Physiology

Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition

D. C. Sarver, J. Garcia-Diaz, M. Saqib, R. C. Riddle, G. W. Wong

This study shows that Tmem263 deletion in mice causes dwarfism and skeletal issues by disrupting the GH/IGF-1 axis, linking TMEM263 to growth regulation.

bioRxiv · Aug 2, 2023Physiology

Hypermetabolism in mice carrying a near complete human chromosome 21

D. C. Sarver, C. Xu, S. Rodriguez, S. Aja, A. E. Jaffe, F. J. Gao, M. Delannoy, M. Periasamy, Y. Kazuki, M. Oshimura, R. H. Reeves, G. W. Wong

This study shows that mice with a human chromosome 21 exhibit hypermetabolism, hyperactivity, and increased insulin sensitivity due to sarcolipin overexpression in skeletal muscle.

bioRxiv · Jan 30, 2023Physiology

PDE9 Inhibition Activates PPARa to Stimulate Mitochondrial Fat Metabolism and Reduce Cardiometabolic Syndrome

S. Mishra, V. Hahn, N. Sadagopan, B. Dunkerly-Eyring, S. Rodriguez, D. C. Sarver, R. P. Ceddia, S. Murphy, H. Knutsdottir, V. Jani, D. Ashok, C. U. Oeing, B. O'Rourke, K. Sharma, J. Gangoiti, , D. A. Kass

This study shows PDE9 inhibition activates PPARa to enhance mitochondrial fat metabolism and reduce cardiometabolic syndrome in mice, with potential for treating obesity in men and postmenopausal women.

bioRxiv · Feb 2, 2021 · PreprintPhysiology

Local Shifts in Inflammatory and Resolving Lipid Mediators in Response to Tendon Overuse

J. F. Markworth, K. B. Sugg, D. C. Sarver, K. R. Maddipati, S. V. Brooks

This study identifies delayed and prolonged inflammatory responses in overused tendons, marked by elevated pro-inflammatory eicosanoids and reduced pro-resolving lipid mediators.

bioRxiv · Jan 8, 2021Immunology

Obesity alters Ace2 and Tmprss2 expression in lung, trachea, and esophagus in a sex-dependent manner: Implications for COVID-19

D. C. Sarver, G. W. Wong

This study shows obesity and sex influence Ace2 and Tmprss2 expression in lung, trachea, and esophagus, potentially affecting SARS-CoV-2 infection risk and severity.

bioRxiv · Oct 13, 2020Physiology

Immunoresolvents Support Skeletal Myofiber Regeneration via Actions on Myeloid and Muscle Stem Cells

J. F. Markworth, L. A. Brown, E. Lim, C. Floyd, J. Larouche, J. A. Castor-Macias, K. B. Sugg, D. C. Sarver, P. C. F. Macpherson, C. Davis, C. A. Aguilar, K. R. Maddipati, S. V. Brooks

This study shows that resolvin D1 promotes skeletal muscle regeneration by modulating myeloid cells and muscle stem cells, improving recovery without directly affecting myogenesis.

bioRxiv · Jun 12, 2020Immunology

Prostaglandin D2 Signaling is Not Involved in the Recovery of Rat Hindlimb Tendons from Injury

D. C. Sarver, K. B. Sugg, J. R. Talarek, J. B. Swanson, D. J. Oliver, A. C. Hinken, H. F. Kramer, C. L. Mendias

This study investigates the role of PGD2 signaling in tendon healing and finds that inhibiting HPGDS does not improve tendon recovery in rats.

bioRxiv · Nov 10, 2019 · PreprintPhysiology

Multiomics Analysis of the mdx/mTR Mouse Model of Duchenne Muscular Dystrophy

D. W. Van Pelt, Y. A. Kharaz, D. C. Sarver, L. R. Eckhardt, J. T. Dzierzawski, N. P. Disser, A. N. Piacentini, E. Comerford, B. McDonagh, C. L. Mendias

The paper uses multiomics analysis to study dystrophic muscles in mdx/mTR mice, finding transcriptome and proteome changes related to protein balance and metabolism, with limited agreement between transcriptome and proteome fold changes.

bioRxiv · Oct 25, 2019Physiology

Insulin-like growth factor 1 receptor signaling in tenocytes is required for adult tendon growth

N. P. Disser, K. B. Sugg, J. R. Talarek, D. C. Sarver, B. J. Rourke, C. L. Mendias

This study shows that IGF1 signaling in tenocytes is essential for postnatal tendon growth in response to mechanical loading.

bioRxiv · Jun 18, 2019Physiology

Postnatal Tendon Growth and Remodeling Requires Platelet-Derived Growth Factor Receptor Signaling

K. B. Sugg, J. F. Markworth, N. P. Disser, A. M. Rizzi, J. R. Talarek, D. C. Sarver, S. V. Brooks, C. L. Mendias

This study shows PDGFR signaling is essential for postnatal tendon growth and remodeling, with MT1-MMP mediating fibroblast migration and being regulated by PI3K/Akt and ERK1/2.

bioRxiv · Oct 25, 2017Physiology