G. W. Wong

Loss of CTRP10 results in female obesity with preserved metabolic health

This study shows that loss of CTRP10 in female mice leads to obesity without metabolic complications, highlighting a sex-dependent role in metabolic health.

Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition

This study shows that Tmem263 deletion in mice causes dwarfism and skeletal issues by disrupting the GH/IGF-1 axis, linking TMEM263 to growth regulation.

Hypermetabolism in mice carrying a near complete human chromosome 21

This study shows that mice with a human chromosome 21 exhibit hypermetabolism, hyperactivity, and increased insulin sensitivity due to sarcolipin overexpression in skeletal muscle.

Adipokine C1q/Tumor necrosis factor-related protein 3 (CTRP3) Attenuates Intestinal Inflammation via Histone Deacetylase Sirtuin 1 (SIRT1)/NF-κB Signaling

This study shows that CTRP3 reduces intestinal inflammation in colitis models and IBD patients by modulating SIRT1/NF-κB signaling to suppress pro-inflammatory cytokines.

PDE9 Inhibition Activates PPARa to Stimulate Mitochondrial Fat Metabolism and Reduce Cardiometabolic Syndrome

This study shows PDE9 inhibition activates PPARa to enhance mitochondrial fat metabolism and reduce cardiometabolic syndrome in mice, with potential for treating obesity in men and postmenopausal women.

Obesity alters Ace2 and Tmprss2 expression in lung, trachea, and esophagus in a sex-dependent manner: Implications for COVID-19

This study shows obesity and sex influence Ace2 and Tmprss2 expression in lung, trachea, and esophagus, potentially affecting SARS-CoV-2 infection risk and severity.

Glucose transporter expression and regulation following a fast in the ruby-throated hummingbird, Archilochus colubris.

This study examines glucose transporter expression and regulation in ruby-throated hummingbirds during fasting, finding reduced glucose uptake capacity and sustained fructose uptake.