Author

M. Scaltriti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. A. Ku· 1 shared A. Gris-Oliver· 1 shared A. Karabajakian· 1 shared A. L. Wolfe· 1 shared A. Letai· 1 shared A. Mock· 1 shared A. Shnerb· 1 shared B. Joshua· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

A. A. Ku

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

MEK1/2 inhibition transiently alters the tumor immune microenvironment to enhance immunotherapy efficacy against head and neck cancer

M. Prasad, J. Zorea, S. Jagadeeshan, A. Shnerb, J. Bouaoud, L. Michon, O. Novoplansky, M. Badarni, L. Cohen, K. Yagodayev, S. Tzadok, B. Rotblat, L. Brezina, A. Mock, A. Karabajakian, , M. Elkabets

This study shows that MEK1/2 inhibition temporarily improves the tumor immune microenvironment, enhancing immunotherapy effectiveness in head and neck cancer by reducing suppressive myeloid cells and boosting CD8+ T cell activity.

bioRxiv · Aug 22, 2021Cancer Biology

UDP-glucose pyrophosphorylase 2, a regulator of glycosylation and glycogen, is essential for pancreatic cancer growth

A. L. Wolfe, Q. Zhou, E. Toska, J. Galeas, A. A. Ku, R. P. Koche, S. Bandyopadhyay, M. Scaltriti, C. B. Lebrilla, F. McCormick, S. E. Kim

This study identifies UGP2 as essential for pancreatic cancer growth by regulating glycogen and N-glycosylation, with potential therapeutic implications.

bioRxiv · Oct 13, 2020 · PreprintCancer Biology

Personalized Cancer Therapy Prioritization Based on Driver Alteration Co-occurrence Patterns

L. Mateo, M. Duran-Frigola, A. Gris-Oliver, M. Palafox, M. Scaltriti, P. Razavi, S. Chandarlapaty, J. Arribas, M. Bellet, V. Serra, P. Aloy

The paper identifies actionable genomic vulnerabilities in cancer by analyzing driver alteration co-occurrence patterns and validates predictions in mice, improving drug response modeling from patient data.

bioRxiv · Sep 18, 2020Cancer Biology

Cell line-specific network models of ER+ breast cancer identify PI3Kα inhibitor sensitivity factors and drug combinations

J. Gomez Tejeda Zanudo, P. Mao, C. Alcon, K. J. Kowalski, G. N. Johnson, G. Xu, J. Baselga, M. Scaltriti, A. Letai, J. Montero, R. Albert, N. Wagle

bioRxiv · Aug 25, 2020Cancer Biology