Author

A. Marin-Gonzalez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

F. Moreno-Herrero· 3 shared J. G. Vilhena· 3 shared R. Perez· 3 shared A. Martin-Gonzalez· 2 shared C. Aicart-Ramos· 2 shared R. S. Zou· 2 shared T. Ha· 2 shared Y. Liu· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiophysics

F. Moreno-Herrero

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Improving the sensitivity of in vivo CRISPR off-target detection with DISCOVER-Seq+

R. S. Zou, Y. Liu, O. E. Reyes Gaido, M. F. Konig, B. J. Mog, L. L. Shen, F. Aviles-Vazquez, A. Marin-Gonzalez, T. Ha

DISCOVER-Seq+ improves CRISPR off-target detection sensitivity by using DNA-PKcs inhibition and ChIP-seq to identify more off-target sites in cells and mice.

bioRxiv · Oct 29, 2022Bioengineering

Massively parallel genomic perturbations with multi-target CRISPR reveal new insights on Cas9 activity and DNA damage responses at endogenous sites

R. S. Zou, A. Marin-Gonzalez, Y. Liu, H. B. Liu, L. Shen, R. Dveirin, J. X. J. Luo, R. Kalhor, T. Ha

This paper introduces multi-target gRNAs (mgRNAs) to enable high-throughput CRISPR screening, revealing insights into Cas9 dynamics, DNA damage responses, and chromatin changes at endogenous sites.

bioRxiv · Jan 18, 2022 · PreprintCell Biology

Double-stranded RNA bending by AU-tract sequences

A. Marin-Gonzalez, C. Aicart-Ramos, M. Marin-Baquero, A. Martin-Gonzalez, M. Suomalainen, A. Kannan, J. G. Vilhena, U. F. Greber, F. Moreno-Herrero, R. Perez

The paper identifies AU-tracts in dsRNA that cause structural bending through molecular dynamics simulations and AFM experiments.

bioRxiv · Feb 17, 2020Biophysics

Understanding the paradoxical mechanical response of in-phase A-tracts at different force regimes

A. Marin-Gonzalez, C. L. Pastrana, R. Bocanegra, A. Martin-Gonzalez, J. G. Vilhena, R. Perez, B. Ibarra, C. Aicart-Ramos, F. Moreno-Herrero

This study investigates the mechanical behavior of A-tracts across different force regimes using single-molecule experiments and polymer models, revealing intrinsic bending and unusual stiffness.

bioRxiv · Nov 26, 2019Biophysics

DNA crookedness regulates DNA mechanical properties at short length scales

A. Marin-Gonzalez, J. G. Vilhena, F. Moreno-Herrero, R. Perez

The paper quantifies DNA crookedness and shows it correlates with DNA stiffness, linking sequence structure to mechanical properties and gene expression.

bioRxiv · Mar 16, 2018Biophysics