A. Kannan

Runx1 regulates critical factors that control uterine angiogenesis and trophoblast differentiation during placental development

This study shows that Runx1 regulates decidual angiogenesis and trophoblast differentiation in placental development by controlling genes like GJA1 and IGF2.

Sounding the alarm: sex differences in rat ultrasonic vocalizations during Pavlovian fear conditioning and extinction

This study examines sex differences in rat ultrasonic vocalizations during fear conditioning and extinction, finding males emit more alarm calls and show stronger correlations between alarm calls and freezing behavior.

Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton

This study shows that TFR1-mediated iron uptake in osteoclasts affects mitochondrial function and cytoskeleton, leading to increased bone mass in female mice.

CYP1B1 converts procarcinogens into genotoxins in Saccharomyces cerevisiae

This study shows that CYP1B1 converts carcinogens into genotoxins in yeast, increasing DNA damage and translocations but not mutations.

Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic andtargetable tissue states

The paper identifies three tissue states in glioblastoma microenvironments using snRNAseq and spatial transcriptomics, linking them to metabolic pathways and clinical outcomes.

Irx3 Promotes Gap Junction Communication Between Uterine Stromal Cells to Regulate Vascularization during Embryo Implantation

This study shows that IRX3 in uterine stromal cells promotes vascularization during embryo implantation, supporting successful pregnancy.

Engineering Insulin Cold Chain Resilience to Improve Global Access

This paper develops amphiphilic copolymers to enhance insulin formulation resilience, enabling storage without refrigeration for over 6 months and improving global access to insulin.

Cell-to-cell and genome-to-genome variability of Adenovirus transcription tuned by the cell cycle

This study investigates cell-to-cell and genome-to-genome variability in adenovirus transcription and replication, finding that host cell cycle state influences viral gene expression and genome activity.

Double-stranded RNA bending by AU-tract sequences

The paper identifies AU-tracts in dsRNA that cause structural bending through molecular dynamics simulations and AFM experiments.

Comparative genomics for the elucidation of multidrug resistance (MDR) in Candida lusitaniae

This paper identifies six non-synonymous SNPs associated with multidrug resistance in Candida lusitaniae through comparative genomics and functional validation.

Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA

This paper uses machine learning on whole-genome sequencing of plasma cell-free DNA to detect early-stage colorectal cancer with high sensitivity and specificity.