M. Toner

Tumor cell-based liquid biopsy using high-throughput microfluidic enrichment of entire leukapheresis product

This study uses high-throughput microfluidic technology to enrich CTCs from large blood volumes, enabling detailed molecular and morphological analysis of tumor cells in metastatic cancer patients.

Optimization of liver graft function using a poly-pharmacological drug cocktail CEPT in a simulated transplant model

This study evaluates the effect of the drug cocktail CEPT on liver graft function during simulated transplantation, finding improved cellular function and reduced apoptosis markers.

High throughput intracellular delivery by viscoelastic mechanoporation

This paper introduces a contact-free mechanoporation method using viscoelastic flow forces for efficient intracellular delivery of biomolecules to mammalian cells.

A Microfluidic Transistor for Liquid Signal Processing

This paper introduces a microfluidic transistor that mimics electronic transistor behavior, enabling fluidic circuit design for liquid signal processing and single-particle manipulation.

The role of antifreeze glycopeptides (AFGP) and polyvinyl alcohol/polyglycerol (X/Z-1000) cocktails as ice modulators during partial freezing of rat livers.

This paper evaluates the effects of AFGP and X/Z-1000 ice modulators on the viability and structure of partially frozen rat livers, finding varying impacts on ATP levels, edema, and endothelial damage.

Single cell proteomics of tumor compartments identifies differential kinase activities defining sensitivity to mTOR-PI3-kinase inhibition

The paper uses single cell proteomics to identify kinase activity differences in tumor compartments, showing how they affect sensitivity to mTOR-PI3K inhibition.

Cryopreservation of Infectious Cryptosporidium parvum Oocysts

This study develops a method to cryopreserve Cryptosporidium parvum oocysts using ultra-fast cooling, maintaining their viability and infectivity for several weeks.