D. T. Ting

Tumor cell-based liquid biopsy using high-throughput microfluidic enrichment of entire leukapheresis product

This study uses high-throughput microfluidic technology to enrich CTCs from large blood volumes, enabling detailed molecular and morphological analysis of tumor cells in metastatic cancer patients.

CDKN1B (p27kip1) enhances drug tolerant persister CTCs by restricting polyploidy following mitotic inhibitors.

This study identifies CDKN1B as a regulator of drug-tolerant persister CTCs by preventing polyploidy after mitotic inhibitor treatment in breast cancer.

Single Cell Spatial Transcriptomic Profiling Identifies a LINE1 Associated Disarrayed Immune Microenvironment in Hepatocellular Carcinoma

This study uses single cell spatial transcriptomics to show LINE1 repeat RNA expression in HCC correlates with a disorganized immune microenvironment and poor patient survival.

Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysis

This study uses single-cell spatial transcriptomics and optimal transport analysis to reveal therapy-induced changes in pancreatic cancer microenvironment interactions.

Cancer cells co-evolve with retrotransposons to mitigate viral mimicry

This study shows pancreatic tumors co-evolve with retrotransposons to modulate immune responses by regulating viral mimicry through SINEs and L1 retrotransposition.

Inflammatory Signaling in Pancreatic Cancer Transfers Between a Single-cell RNA Sequencing Atlas and Co-Culture

This paper integrates single-cell RNA sequencing data with organoid co-cultures to study inflammatory signaling in pancreatic cancer and validates findings through transfer learning and mechanistic experiments.

Single cell proteomics of tumor compartments identifies differential kinase activities defining sensitivity to mTOR-PI3-kinase inhibition

The paper uses single cell proteomics to identify kinase activity differences in tumor compartments, showing how they affect sensitivity to mTOR-PI3K inhibition.

Global Cancer Transcriptome Quantifies Repeat Element Polarization Between Immunotherapy Responsive and T cell Suppressive Classes

The paper quantifies repeat element polarization in cancer transcriptomes to identify biomarkers for immunotherapy response and tumor microenvironment immunosuppression.