High-resolution double vision of the archetypal protein tyrosine phosphatase
S. Sharma, T. Mehlman, R. S. Sagabala, B. Boivin, D. A. Keedy
This study presents the highest-resolution crystal structure of apo PTP1B, revealing conformational heterogeneity and highlighting how mutations enhance local dynamics.
bioRxiv · Sep 12, 2023Biophysics