Author

M. U. Kaikkonen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A.-L. Levonen· 2 shared I. Selvarajan· 2 shared J. Harkonen· 2 shared T. Örd· 2 shared A. Baker· 1 shared A. Ekman· 1 shared A. Gupta· 1 shared A. J. Deen· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCancer Biology

A.-L. Levonen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Progression of herpesvirus infection remodels mitochondrial organization and metabolism

S. Leclerc, A. Gupta, V. Ruokolainen, J.-H. Chen, K. Kunnas, A. Ekman, H. Niskanen, I. Belevich, H. Vihinen, P. Turkki, A. Perez-Berna, S. Kapishnikov, E. Mäntylä, M. Harkiolaki, E. Dufour, , M. Vihinen-Ranta

This study shows how herpesvirus infection alters mitochondrial structure and metabolism during infection progression.

bioRxiv · Nov 16, 2023 · PreprintMicrobiology

Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells

A. J. Deen, S. Adinolfi, J. Harkonen, T. Patinen, X. Liu, T. Laitinen, P. Takabe, K. Kainulainen, S. Pasonen-Seppanen, L. Gawriyski, U. Thanigai Arasu, I. Selvarajan, P. Makinen, H. Laitinen, E. Kansanen, , A.-L. Levonen

This study shows that KEAP1 mutations in lung cancer activate TRAF2-NFκB signaling, enhancing cell survival by preventing apoptosis.

bioRxiv · Oct 10, 2023Cancer Biology

Colchicine promotes atherosclerotic plaque stability independently of inflammation

W. Li, A. Lin, M. Hutton, H. Dhaliwal, J. Nadel, J. Rodor, S. Tumanov, T. Örd, M. Hadden, M. Mokry, B. M. Mol, G. Pasterkamp, M. P. Padula, C. L. Geczy, Y. Ramaswamy, , A. Misra

This study shows colchicine stabilizes atherosclerotic plaques by converting harmful SMC-derived cells into protective myofibroblast-like cells, independent of its anti-inflammatory effects.

bioRxiv · Oct 3, 2023 · PreprintCell Biology

ErbB Signalling is a Potential Therapeutic Target for Vascular Lesions with Fibrous Component

H. Ilmonen, S. Jauhiainen, P. Vuola, H. Rasinkangas, H. H. Pulkkinen, S. Keränen, M. Kiema, J. J. Liikkanen, N. Laham-Karam, S. Laidinen, E. Aavik, K. Lappalainen, J. Lohi, J. Aronniemi, T. Örd, , J. P. Laakkonen

This study identifies ErbB signaling as a therapeutic target for vascular lesions with fibrous components by showing TGFA/VEGF-A paracrine signaling and the effect of PIK3CA mutations.

bioRxiv · Sep 23, 2022 · PreprintCell Biology

Pan-cancer scale screening reveals NRF2 associated immunoevasive characteristics in non-small cell lung cancer and squamous malignancies

J. Harkonen, P. Polonen, A. Jawahar-Deen, I. Selvarajan, H.-R. Teppo, E. Dimova, T. Kietzmann, M. Ahtiainen, T. Eklund, T. Kuopio, E.-M. Talvitie, P. Taimen, M. Kallajoki, M. U. Kaikkonen, M. Heinaniemi, A.-L. Levonen

This paper identifies NRF2-associated immunoevasive features in NSCLC and squamous cancers, linking NRF2 activity to immune-cold phenotypes and potential biomarkers for immune checkpoint response.

bioRxiv · May 15, 2022 · PreprintCancer Biology