C-di-AMP levels modulate Staphylococcus aureus cell wall thickness as well as virulence and contribute to antibiotic resistance and tolerance
V. Dengler Haunreiter, A. Tarnutzer, J. Baer, M. von Matt, S. Hertegonne, F. Andreoni, C. Vulin, L. Künzi, C. Menzi, P. Kiefer, P. Christen, J. A. Vorholt, A. S. Zinkernagel
This study shows that high c-di-AMP levels in Staphylococcus aureus increase cell wall thickness and antibiotic resistance, while reducing cell size and antioxidant production.
bioRxiv · Apr 18, 2023Microbiology