Author

M. Wieczorek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:cryo-EM· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

B. T. Chait· 2 shared K. R. Molloy· 2 shared L. Urnavicius· 2 shared S.-C. Ti· 2 shared T. M. Kapoor· 2 shared A. Aher· 1 shared A. Akhmanova· 1 shared D. Rai· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

B. T. Chait

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Author profile →

4 papers

Recent·Most cited

Closure of the gamma-tubulin ring complex by CDK5RAP2 activates microtubule nucleation

Y. Xu, H. Munoz-Hernandez, R. Krutyholowa, F. Marxer, F. Cetin, M. Wieczorek

This study determines the structure of the gamma-tubulin ring complex (gamma-TuRC) activated by CDK5RAP2 and shows how it promotes microtubule nucleation by closing the gamma-tubulin ring.

bioRxiv · Dec 14, 2023Biochemistry

CAMSAP-driven microtubule release from γ-TuRC and its regulation by nucleation-promoting factors

D. Rai, S. Hua, J. L. Monster, R. Stucchi, K. Stecker, Y. Zhang, E. A. Katrukha, M. A. Altelaar, M. Wieczorek, K. Jiang, A. Akhmanova

This study investigates how CAMSAP proteins and CDK5RAP2 regulate microtubule release from γ-TuRC, revealing their roles in microtubule nucleation and stabilization.

bioRxiv · Aug 3, 2022 · PreprintCell Biology

Biochemical reconstitutions reveal principles of human γ-TuRC assembly and function

M. Wieczorek, S.-C. Ti, L. Urnavicius, K. R. Molloy, A. Aher, B. T. Chait, T. M. Kapoor

This paper reconstitutes the human γ-TuRC and analyzes its structure and function, showing that the lumenal bridge is essential for microtubule nucleation.

bioRxiv · Sep 21, 2020Biochemistry

Asymmetric molecular architecture of the human γ-tubulin ring complex

M. Wieczorek, L. Urnavicius, S.-C. Ti, K. R. Molloy, B. T. Chait, T. M. Kapoor

This study presents a cryo-EM structure of the native human γ-tubulin ring complex, revealing its asymmetric architecture and identifying new structural features and interactions.

bioRxiv · Oct 25, 2019Biochemistry