Y. Tachibana

In vivo CRISPR screens identify novel virulence genes among proteins of unassigned subcellular localization in Toxoplasma

The paper uses in vivo CRISPR screens to identify virulence genes among Toxoplasma proteins with unassigned subcellular localizations, finding two essential genes conserved in Apicomplexa.

Distribution of intraperitoneally administered D2O in AQP4-knockout mouse brain after MCA occlusion

This study uses D2O and MRI to assess how AQP4 loss affects water dynamics in the brain after focal ischemia, finding delayed signal changes in AQP4-knockout mice.

Discovery of S-217622, a Non-Covalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19

This paper describes the discovery of S-217622, an oral non-covalent SARS-CoV-2 3CL protease inhibitor showing antiviral activity and favorable pharmacokinetics in preclinical studies.

Quantitative Measurement of Diffusion-weighted Imaging Signal Using Expression-controlled Aquaporin-4 Cells: Comparative Study of 2-compartment and Diffusion Kurtosis Imaging Models

This study compares 2-compartment and diffusion kurtosis imaging models to assess how AQP4 expression affects diffusion-weighted imaging signal parameters in cell suspensions.

Htr6 and Sstr3 ciliary targeting relies on both IC3 loops and C-terminal tails

This study identifies additional ciliary targeting sequences in Htr6 and Sstr3 beyond their IC3 loops, showing redundancy between IC3 and C-terminal tail CTSs.