Author

M. Zagnoni

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Hedley· 1 shared C. Boldrini· 1 shared C. Jamieson· 1 shared C. Miller· 1 shared C. Riero Domingo· 1 shared D. Athineos· 1 shared D. Sumpton· 1 shared E. Gjerga· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. Hedley

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Assessment of CAR-T mediated and targeted cytotoxicity in 3D microfluidic TBNC co-culture models for combination therapy

K. A. F. Paterson, S. Paterson, T. Mulholland, S. B. Coffelt, M. Zagnoni

This study evaluates CAR-T cytotoxicity in 3D microfluidic models of triple-negative breast cancer, showing enhanced efficacy with combination therapy.

bioRxiv · Sep 14, 2021 · PreprintBioengineering

PYCR1-dependent proline synthesis in cancer-associated fibroblasts is required for the deposition of pro-tumorigenic extracellular matrix

E. J. Kay, K. Paterson, C. Riero Domingo, D. Sumpton, H. Daebritz, S. Tardito, C. Boldrini, J. R. Hernandez-Fernaud, D. Athineos, S. Dhayade, E. Stepanova, E. Gjerga, L. J. Neilson, S. Lilla, A. Hedley, , S. Zanivan

This study identifies PYCR1-dependent proline synthesis in cancer-associated fibroblasts as critical for collagen production and tumor progression, suggesting PYCR1 as a therapeutic target to inhibit pro-tumorigenic extracellular matrix deposition.

bioRxiv · May 30, 2020 · PreprintCancer Biology

Seeing around corners: Cells create chemotactic gradients to solve mazes and respond to distant cues in complex environments.

L. Tweedy, P. Thomason, K. J. Martin, M. Zagnoni, L. M. Machesky, R. H. Insall

The paper shows cells use self-generated chemotactic gradients to navigate complex environments and solve mazes, with accuracy influenced by path complexity, attractant diffusibility, and cell speed.

bioRxiv · Nov 9, 2019 · PreprintCell Biology