This study shows that low-dose whole-brain irradiation increases the uptake of an anti-HER2 VHH in intracranial tumors, enhancing its theranostic potential for HER2-positive brain metastases.

bioRxiv · Apr 19, 2022Cancer Biology

A New Mouse Model of Diffuse Midline Glioma to Test Targeted Immunotherapies

M. D. Seblani, M. Zannikou, J. Duffy, R. N. Levine, Q. Liu, C. M. Horbinski, O. Becher, I. Balyasnikova

This paper develops a new mouse model of diffuse midline glioma to evaluate IL13R2-targeted immunotherapies, showing tumors with histopathological features of pediatric gliomas.

bioRxiv · Oct 15, 2021Cancer Biology

Neural Stem Cells Secreting Bispecific T Cell Engager to Induce Selective Anti-Glioma Activity

K. C. Pituch, M. Zannikou, L. Ilut, T. Xiao, M. Chastkofsky, M. Sukhanova, N. Bertolino, D. Procissi, C. Amidei, C. Horbinski, K. S. Aboody, C. D. James, M. S. Lesniak, I. V. Balyasnikova

This study develops neural stem cells secreting a bispecific T cell engager (BiTE) to target glioblastoma, showing survival benefits in mice with IL13R2+ tumors.

bioRxiv · Jul 21, 2020Immunology

Interaction between DNA damage response, translation and apoptosome determines cancer susceptibility to TOP2 poisons

C. U. Awah, L. Chen, M. Bansal, A. Mahajan, J. Winter, M. Lad, L. Warnke, E. Gonzalez-Buendia, C. Park, D. Zhang, E. Feldstein, D. Yu, M. Zannikou, I. Balyasnikova, R. Martuscello, , A. M. Sonabend

The paper identifies genes involved in DNA damage response and translation that influence susceptibility to TOP2 poisons in gliomas and other cancers.

bioRxiv · Apr 25, 2019 · PreprintCancer Biology