Targeting MLL methyltransferases enhance the anti-tumor effects of PI3K inhibition in hormone receptor-positive breast cancer
R. B. Jones, J. Farhi, M. Adams, K. Parwani, M. Zecevic, G. Cooper, R. S. Lee, A. L. Hong, J. Spangle
This paper shows that combining PI3K and MLL1 inhibition enhances anti-tumor effects in HR+ breast cancer by disrupting a feedback loop between MLL1 and AKT.
bioRxiv · Oct 1, 2021Cancer Biology