Author

R. S. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2

Frequent Co-Authors

J. Farhi· 3 shared A. H. Corbett· 2 shared A. L. Hong· 2 shared C. Y. Jones· 2 shared J. Spangle· 2 shared K. Sad· 2 shared R. B. Jones· 2 shared A. Bigger-Allen· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCancer Biology

J. Farhi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Integrated omics analysis unveils a DNA damage response to neurogenic injury

A. Hashemi Gheinani, B. S. Sack, A. Bigger-Allen, H. Thaker, H. Atta, G. Lambrinos, K. Costa, C. Doyle, M. Gharaee-Kermani, S. Patalano, M. Piper, J. F. Cotellessa, D. Vitko, H. Li, M. Kadayil Prabhakaran, , R. M. Adam

The paper uses multi-omics analysis to study molecular changes in the bladder after spinal cord injury in rats and identifies DNA damage response pathways modulated by inosine treatment.

bioRxiv · Dec 10, 2023 · PreprintCell Biology

Histone H3 E50K mutation confers oncogenic activity and supports an EMT phenotype

K. Sad, C. Y. Jones, D. V. Fawwal, E. J. Hill, K. Skinner, S. Lustenberger, R. S. Lee, S. R. Elayavalli, J. Farhi, L. D. Lemon, M. B. Fasken, A. L. Hong, S. A. Sloan, A. H. Corbett, J. M. Spangle

This paper shows that the H3E50K mutation in histone H3 promotes oncogenic activity by enhancing cell migration, invasion, and epithelial-mesenchymal transition.

bioRxiv · Oct 11, 2023 · PreprintCancer Biology

Craniofacial diversity across Danionins and the effects of TH status on craniofacial morphology of two Danio species

S. V. Nguyen, R. S. Lee, E. Mohlmann, G. Petrullo, J. Blythe, I. Ranieri, S. McMenamin

The paper examines craniofacial diversity across Danioninae species and shows that thyroid hormone status affects skull morphology in two Danio species.

bioRxiv · Aug 9, 2023 · PreprintEvolutionary Biology

Dynamic in vivo mapping of the methylproteome using a chemoenzymatic approach

J. Farhi, B. Emenike, C. M. Beusch, R. S. Lee, R. B. Jones, A. K. Verma, C. Y. Jones, M. Foroozani, M. Reeves, K. Sad, K. K. Parwani, P. Bagchi, R. Deal, D. J. Katz, A. H. Corbett, , J. Spangle

This paper develops a chemoenzymatic method to map the methylproteome in vivo, identifying known and novel methylation sites across multiple organ systems in mice.

bioRxiv · Jul 22, 2022 · PreprintBiochemistry

Targeting MLL methyltransferases enhance the anti-tumor effects of PI3K inhibition in hormone receptor-positive breast cancer

R. B. Jones, J. Farhi, M. Adams, K. Parwani, M. Zecevic, G. Cooper, R. S. Lee, A. L. Hong, J. Spangle

This paper shows that combining PI3K and MLL1 inhibition enhances anti-tumor effects in HR+ breast cancer by disrupting a feedback loop between MLL1 and AKT.

bioRxiv · Oct 1, 2021Cancer Biology