Author

J. Spangle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

J. Farhi· 2 shared R. B. Jones· 2 shared R. S. Lee· 2 shared A. H. Corbett· 1 shared A. K. Verma· 1 shared A. L. Hong· 1 shared B. Emenike· 1 shared C. M. Beusch· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

J. Farhi

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Dynamic in vivo mapping of the methylproteome using a chemoenzymatic approach

J. Farhi, B. Emenike, C. M. Beusch, R. S. Lee, R. B. Jones, A. K. Verma, C. Y. Jones, M. Foroozani, M. Reeves, K. Sad, K. K. Parwani, P. Bagchi, R. Deal, D. J. Katz, A. H. Corbett, , J. Spangle

This paper develops a chemoenzymatic method to map the methylproteome in vivo, identifying known and novel methylation sites across multiple organ systems in mice.

bioRxiv · Jul 22, 2022 · PreprintBiochemistry

Targeting MLL methyltransferases enhance the anti-tumor effects of PI3K inhibition in hormone receptor-positive breast cancer

R. B. Jones, J. Farhi, M. Adams, K. Parwani, M. Zecevic, G. Cooper, R. S. Lee, A. L. Hong, J. Spangle

This paper shows that combining PI3K and MLL1 inhibition enhances anti-tumor effects in HR+ breast cancer by disrupting a feedback loop between MLL1 and AKT.

bioRxiv · Oct 1, 2021Cancer Biology