Author

Nicholas J. Tursi

The Wistar InstituteORCID 0000-0001-6752-3402Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

David B. WeineriD· 2 shared Alana Huynh· 1 shared Amber KimiD· 1 shared Amelia EscolanoiD· 1 shared Ami Patel· 1 shared Ashwin N. SkellyiD· 1 shared Beatrice H. HahniD· 1 shared Brian T. GaudetteiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

David B. WeinerORCID

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2 papers

Recent·Most cited

Notch2 signaling instructs viral and bacterial TLR responsiveness in B cells

Jennifer Londregan, Isaiah Rozich, Brian T. Gaudette, Jeffrey R. Maslanka, Rachel Serafin, Nicholas J. Tursi, Sarah Naiyer, Scott E. Hensley, David B. Weiner, Ivan P. Maillard, David Allman

This study shows Notch2 signaling enhances TLR3 and TLR4 responsiveness in MZ B cells, promoting immune responses to viral and bacterial pathogens.

Cell Reports · Jul 30, 2026Peer-reviewedImmunology

Deep Mining of the Human Antibody Repertoire Identifies Frequent and Genetically Diverse CDRH3 Topologies Targetable by Vaccination

Rumi Habib, Shahlo O. Solieva, Zi Jie Lin, Sukanya Ghosh, Kelly Bayruns, Maya Singh, Colby J. Agostino, Nicholas J. Tursi, Kirsten J. Sowers, Jinwei Huang, Ryan S. Roark, Mansi Purwar, Younghoon Park, Kasirajan Ayyanathan, Hui Li, , Daniel W. Kulp

The paper identifies frequent and genetically diverse CDRH3 topologies in the human antibody repertoire that can be targeted by vaccination to elicit broadly neutralizing antibodies.

Proceedings of the National Academy of Sciences · Apr 29, 2026Peer-reviewedImmunology