The viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape
Charlotte Vandermeulen, Tina M. O’Grady, Jérôme Wayet, Bartimée Galvan, Sibusiso B. Maseko, Majid Cherkaoui, Alice Desbuleux, Georges Coppin, Julien Olivet, Lamya Ben Ameur, Keisuke Kataoka, Seishi Ogawa, Olivier Hermine, Ambroise Marçais, Marc Thiry, , Jean‐Claude Twizere
This study shows that Tax and HBZ, viral oncoproteins, alter mRNA splicing in T-cells by interacting with spliceosome components, leading to changes in cancer-related genes.
PLoS Pathogens · Sep 20, 2021Peer-reviewedSystems Biology