Jean‐Claude Twizere

Persistent circulation of Rift Valley fever virus lineage C in Rwanda, 2022-2025

This study shows Rift Valley fever virus lineage C circulates persistently in Rwanda through local transmission, not repeated introductions, based on whole-genome sequencing of livestock samples from 2022-2025.

Conserved metabolic vulnerabilities across pathogenic coronaviruses nominate host-directed therapeutic targets

The paper identifies conserved metabolic vulnerabilities across SARS-CoV, SARS-CoV-2, and MERS-CoV using transcriptomic data and metabolic models, revealing druggable host targets.

Dynamic engagement of dual-role regulators by the Sin3 complex

The paper investigates how dual-role regulators interact with the Sin3 complex using structural and functional analyses, revealing mechanisms for transcriptional crosstalk.

Multi-omics decipher the molecular mechanisms driving high-lipid production in an artificially-evolved Chlamydomonas mutant

The paper identifies mutations and multi-omic changes in a Chlamydomonas mutant (H5) that enhance lipid production without affecting growth.

A near telomere-to-telomere phased reference assembly for the male mountain gorilla

The paper presents a high-quality, near telomere-to-telomere, haplotype-phased reference genome for a male mountain gorilla using long-read sequencing technologies.

Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms

The paper identifies two categories of transcription factor isoforms with distinct molecular functions and shows they contribute to gene regulatory complexity.

A comprehensive two-hybrid analysis to explore the L. pneumophila effector-effector interactome

The paper uses a yeast two-hybrid screen to identify novel effector-effector interactions in L. pneumophila, doubling the known number of such interactions.

SARS-CoV2 infection triggers reactive astrocyte states and inflammatory conditions in long-term Human Cortical Organoids

This study shows SARS-CoV2 infects brain cells in cortical organoids, inducing reactive astrocyte states and inflammation.

AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor

The paper presents an AI-guided pipeline for PPI drug discovery, identifying a SARS-CoV-2 inhibitor by combining experimental assays, machine learning, and virtual screening.

Expanding the HDAC druggable landscape beyond enzymatic activity

This paper identifies a non-enzymatic HDAC inhibitor with anti-tumor and anti-psychedelic effects, showing reduced gene modulation compared to enzymatic inhibitors.

A map of binary SARS-CoV-2 protein interactions implicates host immune regulation and ubiquitination

The paper maps binary SARS-CoV-2 protein interactions with host proteins, identifying key processes like immune signaling and ubiquitination, and suggests therapeutic targets.

Assessment of community efforts to advance computational prediction of protein-protein interactions

The paper evaluates 24 network-based methods for predicting protein-protein interactions across five interactomes, identifies top-performing methods, and validates their predictions experimentally.

The viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape

This study shows that Tax and HBZ, viral oncoproteins, alter mRNA splicing in T-cells by interacting with spliceosome components, leading to changes in cancer-related genes.

A quantitative mapping approach to identify direct interactions within complexomes

The paper presents a framework combining two high-throughput interaction assays to distinguish direct from indirect protein interactions in complexes.

Binary Interactome Models of Inner- Versus Outer-Complexome Organization

The paper constructs a high-quality yeast binary interactome map and compares inner- and outer-complexome organization, finding the outer-complexome contains more interactions and exhibits higher functional heterogeneity.

Maximizing binary interactome mapping with a minimal number of assays

The paper introduces an assayome concept to optimize binary interactome mapping by combining multiple assay versions, achieving high true positive detection with minimal assays.

A reference map of the human protein interactome

The paper presents HuRI, a comprehensive human protein-protein interaction map, and demonstrates its utility in understanding cellular function and disease mechanisms.