Active site assembly by SMG5 as a mechanism for SMG6 endonuclease licensing in nonsense-mediated mRNA decay
Enes S. Arpa, Michael John Taschner, Mara De Matos, Stefanie Jonas, David Gatfield
The paper investigates how SMG5 licenses SMG6 endonuclease activity in NMD by forming a composite active site with SMG6 PIN domain.
Journal of Molecular Biology · Feb 26, 2026Peer-reviewedMolecular Biology