Author

Margaret L. Coughlin

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1 Organism:yeast· 1

Frequent Co-Authors

Allon Moshe KleiniD· 1 shared Anja E. H. Nordstrom· 1 shared Corrie J.B. daCostaiD· 1 shared Della SyauiD· 1 shared Elizabeth S. Van ItallieiD· 1 shared Friederike M. C. BenningiD· 1 shared Leonid PeshkiniD· 1 shared Louise B. ConnelliD· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperSystems Biology

Allon Moshe KleinORCID

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2 papers

Recent·Most cited

Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast

Friederike M. C. Benning, Tristan A. Bell, Tran H. Nguyen, Della Syau, Louise B. Connell, Yi‐Ting Liao, Matthew P. Keating, Margaret L. Coughlin, Anja E. H. Nordstrom, Maria Ericsson, Corrie J.B. daCosta, Luke H. Chao

This study uses ancestral sequence reconstruction to identify residues in the Mitofilin domain of Mic60 that support respiration in yeast.

Protein Science · Jun 22, 2025Peer-reviewedEvolutionary Biology

Proteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the Xenopus egg

Marc Presler, Elizabeth S. Van Itallie, Allon Moshe Klein, Ryan C. Kunz, Margaret L. Coughlin, Leonid Peshkin, Steven P. Gygi, Martin Wühr, Marc W. Kirschner

The paper quantifies protein and phospho-site dynamics during fertilization and meiotic exit in Xenopus eggs using mass spectrometry-based proteomics, revealing limited degradation and extensive dephosphorylation.

Proceedings of the National Academy of Sciences · Nov 28, 2017Peer-reviewedSystems Biology