Luke H. Chao

In vivo Treatment of a Severe Vascular Disease via a Bespoke CRISPR-Cas9 Base Editor

This paper develops a customized CRISPR-Cas9 base editor to correct the ACTA2 R179H mutation in a mouse model of MSMDS, improving survival and rescuing vascular and neurological phenotypes.

Stress-mediated growth determines E. coli division site morphogenesis

The paper introduces a model to simulate E. coli division site morphology by coupling mechanochemical processes with mechanical stress.

Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast

This study uses ancestral sequence reconstruction to identify residues in the Mitofilin domain of Mic60 that support respiration in yeast.

The aPBP-type cell wall synthase PBP1b plays a specialized role in fortifying the Escherichia coli division site against osmotic rupture

This study identifies PBP1b's specialized role in E. coli division site fortification against osmotic rupture, showing it functions independently of LpoB and requires an extended N-terminus for recruitment by FtsA.

Loss of SARM1 protects against retinal ganglion cell degeneration in Autosomal Dominant Optic Atrophy

This study identifies SARM1 as a key driver of retinal ganglion cell degeneration in ADOA and shows its suppression prevents degeneration phenotypes.