Author

Friederike M. C. Benning

Harvard UniversityORCID 0000-0002-1002-4204Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Organism:yeast· 1

Frequent Co-Authors

Luke H. ChaoiD· 2 shared Anja E. H. Nordstrom· 1 shared Benjamin P. KleinstiveriD· 1 shared C.K. Fong· 1 shared Casey A. MaguireiD· 1 shared Christian Lacks Lino CardenasiD· 1 shared Christiano R. R. AlvesiD· 1 shared Claire E. ShamberiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBioengineering

Luke H. ChaoORCID

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Author profile →

2 papers

Recent·Most cited

In vivo Treatment of a Severe Vascular Disease via a Bespoke CRISPR-Cas9 Base Editor

Christiano R. R. Alves, Sabyasachi Das, Vijai Krishnan, Leillani L. Ha, Lauren R. Fox, Hannah E. Stutzman, Claire E. Shamber, Pazhanichamy Kalailingam, Siobhan McCarthy, Christian Lacks Lino Cardenas, C.K. Fong, Takahiko Imai, Sunayana Mitra, Shuqi Yun, Rachael K. Wood, , Patricia Leonor Musolino

This paper develops a customized CRISPR-Cas9 base editor to correct the ACTA2 R179H mutation in a mouse model of MSMDS, improving survival and rescuing vascular and neurological phenotypes.

Nature Biomedical Engineering · Sep 11, 2025Peer-reviewedBioengineering

Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast

Friederike M. C. Benning, Tristan A. Bell, Tran H. Nguyen, Della Syau, Louise B. Connell, Yi‐Ting Liao, Matthew P. Keating, Margaret L. Coughlin, Anja E. H. Nordstrom, Maria Ericsson, Corrie J.B. daCosta, Luke H. Chao

This study uses ancestral sequence reconstruction to identify residues in the Mitofilin domain of Mic60 that support respiration in yeast.

Protein Science · Jun 22, 2025Peer-reviewedEvolutionary Biology