Netrin-1 Acts as a Guardian of Naive Pluripotency in Human Embryonic Stem Cells
Agathe De Neufville, Etienne Masfaraud, Charbel Alfeghaly, Jan B. Stöckl, Nathalie Doerflinger, Guillaume Marcy, Cloé Rognard, Pierre Osteil, Marie Lantelme, Fabrice Lavial, Claire Chazaud, Thomas Fröhlich, Pierre Savatier, Irène Aksoy
This study shows Netrin-1 supports naive pluripotency in hESCs by modulating epigenetic and signaling pathways, with effects dependent on culture conditions.
bioRxiv · Jul 16, 2026 · PreprintCell Biology