P53 toxicity is a hurdle to CRISPR/CAS9 screening and engineering in human pluripotent stem cells
Robert J. Ihry, Kathleen A. Worringer, Max R. Salick, Elizabeth Frias, Daniel J. Ho, Kraig M. Theriault, Sravya Kommineni, Julie Chen, Marie Sondey, Chaoyang Ye, Ranjit Randhawa, Tripti Kulkarni, Zinger Yang, Gregory McAllister, Carsten Russ, , Ajamete Kaykas
This study shows that CRISPR/Cas9 induces toxicity in human pluripotent stem cells, which is dependent on TP53 and hinders genome engineering.
Nature Medicine · Jun 8, 2018Peer-reviewedMolecular Biology