Large extracellular vesicles containing mitochondria (EVMs) derived from Alzheimer disease cells harbor pathologic functional and molecular profiles and spread mitochondrial dysfunctions
Fanny Eysert, Véronique Legros, Anne-Sophie Gay, Delphine Debayle, Sandra Lacas‐Gervais, Guillaume Chevreux, Michel Bottlaender, Guillaume Dorothée, Frédéric Checler, Marie-Claude Potier, Marie Sarazin, Julien Lagarde, Mounia Chami
This study characterizes large extracellular vesicles containing mitochondria (EVMs) from Alzheimer's Disease cells, showing they carry pathological mitochondrial dysfunction and spread it to recipient cells.
bioRxiv · Jan 8, 2025 · PreprintNeuroscience