Author

Michel Bottlaender

Centre National de la Recherche ScientifiqueORCID 0000-0002-2890-3653Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Julien LagardeiD· 2 shared Marie SaraziniD· 2 shared Anne-Sophie GayiD· 1 shared Axel LegrandiD· 1 shared Benoı̂t DelatouriD· 1 shared Catherine HelmeriD· 1 shared Delphine DebayleiD· 1 shared Fanny EysertiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Julien LagardeORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Experimental and natural peripheral HSV-1 infection: Neurotropism and impact on Alzheimer's disease-related molecular markers

Axel Legrand, Susana Boluda, Marina S. Boukhvalova, Flore Rozenberg, Michel Bottlaender, Julien Lagarde, Marie Sarazin, Catherine Helmer, Morgane Linard, Benoı̂t Delatour

This study investigates the role of HSV-1 infection in Alzheimer's disease by analyzing its impact on Aβ and Tau pathologies in animal models, postmortem brain samples, and AD patients.

bioRxiv · May 12, 2026 · PreprintNeuroscience

Large extracellular vesicles containing mitochondria (EVMs) derived from Alzheimer disease cells harbor pathologic functional and molecular profiles and spread mitochondrial dysfunctions

Fanny Eysert, Véronique Legros, Anne-Sophie Gay, Delphine Debayle, Sandra Lacas‐Gervais, Guillaume Chevreux, Michel Bottlaender, Guillaume Dorothée, Frédéric Checler, Marie-Claude Potier, Marie Sarazin, Julien Lagarde, Mounia Chami

This study characterizes large extracellular vesicles containing mitochondria (EVMs) from Alzheimer's Disease cells, showing they carry pathological mitochondrial dysfunction and spread it to recipient cells.

bioRxiv · Jan 8, 2025 · PreprintNeuroscience