Julien Lagarde

Somatic instability of the C9orf72 repeat expansion in blood differs between patients with amyotrophic lateral sclerosis or frontotemporal dementia.

This study uses optical genome mapping to analyze C9orf72 repeat expansion instability in blood from ALS and FTD patients, finding age-dependent differences in repeat size dynamics between conditions.

Experimental and natural peripheral HSV-1 infection: Neurotropism and impact on Alzheimer's disease-related molecular markers

This study investigates the role of HSV-1 infection in Alzheimer's disease by analyzing its impact on Aβ and Tau pathologies in animal models, postmortem brain samples, and AD patients.

Large extracellular vesicles containing mitochondria (EVMs) derived from Alzheimer disease cells harbor pathologic functional and molecular profiles and spread mitochondrial dysfunctions

This study characterizes large extracellular vesicles containing mitochondria (EVMs) from Alzheimer's Disease cells, showing they carry pathological mitochondrial dysfunction and spread it to recipient cells.