The Kinase CK1α coordinates Initiation and Termination of the cGAS-STING Pathway
Jane Jardine, Marine Tarrillon, Gwennan André‐Grégoire, Kilian Trillet, Vanessa Josso, Laura Merlet, Rosalie Moreau, Célia Jaunasse, Luc Antigny, Séverine Marionneau‐Lambot, François Guillonneau, Alice Boissard, Cécile Henry, Joanna Re, Sophie Barillé‐Nion, , Nicolas Bidère
This study identifies CK1 as a bimodal regulator of the cGAS-STING pathway, showing it both promotes DNA sensing and facilitates signaling termination, with therapeutic implications for cancer.
Cell Death and Differentiation · Aug 5, 2026Peer-reviewedImmunology