Marjorie Pizzarro-Guajardo

This study shows that combining nystatin, taurocholate, and antibiotics, with nanoparticle delivery, reduces recurrent Clostridioides difficile infection by targeting intracellular spores.

This study identifies complement proteins C1q and C3 as interacting with C. difficile spores via CdeM, influencing spore entry, persistence, and recurrence of infection.

This study characterizes the sporulation and germination of Turicibacter sanguinis, revealing unique spore architecture and regulatory mechanisms distinct from Bacilli and Clostridia.

This study analyzes the conservation and variability of BclA proteins across C. difficile clades using genomic data from over 25,000 genomes, revealing clade-specific differences in bclA gene presence and structure.

This study shows that C. difficile toxins TcdA and TcdB remodel fibronectin and vitronectin in intestinal tissue, enhancing spore adherence and internalization, which may contribute to disease recurrence.

This study investigates glycogen metabolism's role in C. difficile virulence, finding that glycogen accumulation enhances spore resilience and disease relapse.