NINJ1 mediates necrosis of Mycobacterium tuberculosis infected human macrophages
Ragnhild SR Sætra, Mathilde Hansen, Shirin Kappelhoff, Marit Bugge, Anne Marstad, Liv Ryan, Pascal Devant, Jonathan C. Kagan, Kristine Freude, Kai Sandvold Beckwith, Trude Helen Flo
This study identifies NINJ1 as a mediator of plasma membrane rupture in Mtb-infected macrophages, showing it operates independently of canonical cell death pathways and requires the ESX-1 secretion system.
bioRxiv · Nov 4, 2025 · PreprintMicrobiology