Prostaglandin E2 facilitates reciprocal crosstalk between intestinal smooth muscle tissue and epithelium in tumor development
Rouan Yao, Lilith Sian Kaspersen Lee, Marion Duchemin, Alberto Díez-Sánchez, Andrew Single, Anne Marstad, Unni Nonstad, Animesh Sharma, Håvard T. Lindholm, Lars Hagen, Mesut Bilgin, Menno J. Oudhoff, Mara Martín-Alonso
The paper identifies Prostaglandin E2 as a key mediator of crosstalk between intestinal smooth muscle tissue and epithelium in tumor development, showing reciprocal effects on both cell types.
bioRxiv · Jun 12, 2026 · PreprintMolecular Biology